Effects of cross-fostering experience on emotion in adolescent Kunming mice

Abstract Parent–infant bonds are critical early postnatal environment in mammals. Unstable parent–infant bonds, such as maternal separation, paternal deprivation, and neonatal social isolation have negative effects on emotion, cognition, addiction, behaviours the animal’s whole lifespan. Another unstable bond, cross-fostering, which pups were randomly exchanged to other parents has mostly focused kin recognition anxiety-like behavioural changes adult. But its adolescence, particularly autism spectrum disorder, poorly understood. Whole cross-fostering model was used present study. The results showed that with adolescent Kunming mice buried more marbles, expressed higher levels of anxiety depression. Cross-fostering attenuated prosocial reduced activity adolescence when encountering another individual interaction test. Taken together, our demonstrate experiencing life is likely induce autism-, anxiety-, depression- like adolescence.